ABSTRACT
Objective: To determine the frequency of acute complications of hemodialysis in adult age group at a tertiary care centre
Study Design: Descriptive study
Place and Duration of Study: Department of Medicine, Combined Military Hospital Lahore, from Apr 2012 to Oct 2012
Patients and Methods: We included 100 consecutive patients of chronic kidney disease on hemodialysis with age more than 12 years. Personal profile, comorbidities, intravenous access type and duration, hemodialysis parameters were recorded for each patient. Monitoring of blood pressure, temperature, pulse and history of palpitations, headache, nausea, vomiting, muscle cramps, fever, shivering, chest-pain, bleeding, fits, itching was recorded before and up till one hour post hemodialysis session
Results: In our study population fever was the commonest complication with frequency of 37 percent, followed by nausea and vomiting in 36 percent, muscle cramps in 28 percent, hypotension in 24 percent, headache in 23 percent, shivering in 22 percent, chest Pain in 15 percent, itching in 14 percent, hypertension in 10 percent, cardiac arrhythmias in 8 percent, hemorrhage in 7 percent and Seizures in 7 percent of patients
Conclusion: Infection related complications were more common in our set up as compared to international statistics which depicts that we should improve our antiseptic techniques
ABSTRACT
Background: Protein structural alignment is one of the most fundamental and crucial areas of research in the domain of computational structural biology. Comparison of a protein structure with known structures helps to classify it as a new or belonging to a known group of proteins. This, in turn, is useful to determine the function of protein, its evolutionary relationship with other protein molecules and grasping principles underlying protein architecture and folding. Results: A large number of protein structure alignment methods are available. Each protein structure alignment tool has its own strengths and weaknesses that need to be highlighted. We compared and presented results ofsix most popular and publically available servers for protein structure comparison. These web-based servers were compared with the respect to functionality (features provided by these servers) and accuracy (how well the structural comparison is performed). The CATH was used as a reference. The results showed that overall CE was top performer. DALI and PhyreStorm showed similar results whereas PDBeFold showed the lowest performance. In case of few secondary structural elements, CE, DALI and PhyreStorm gave 100% success rate. Conclusion: Overall none of the structural alignment servers showed 100% success rate. Studies of overall performance, effect of mainly alpha and effect of mainly beta showed consistent performance. CE, DALI, FatCat and PhyreStorm showed more than 90% success rate.